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Third row transition metals for the treatment of cancer

Platinum compounds are a mainstay of cancer chemotherapy, with over 50% of patients receiving platinum. But there is a great need for improvement. Major features of the cisplatin mechanism of action involve cancer cell entry, formation mainly of intrastrand cross-links that bend and unwind nuclear D...

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Detalhes bibliográficos
Publicado no:Philos Trans A Math Phys Eng Sci
Main Authors: Johnstone, Timothy C., Suntharalingam, Kogularamanan, Lippard, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society Publishing 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342973/
https://ncbi.nlm.nih.gov/pubmed/25666060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsta.2014.0185
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