Punctuated Copy Number Evolution and Clonal Stasis in Triple-Negative Breast Cancer

Aneuploidy is a hallmark of breast cancer; however, our knowledge of how these complex genomic rearrangements evolve during tumorigenesis is limited. In this study we developed a highly multiplexed single-nucleus-sequencing method to investigate copy number evolution in triple-negative breast cancer...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Gao, Ruli, Davis, Alexander, McDonald, Thomas O., Sei, Emi, Shi, Xiuqing, Wang, Yong, Tsai, Pei-Ching, Casasent, Anna, Waters, Jill, Zhang, Hong, Meric-Bernstam, Funda, Michor, Franziska, Navin, Nicholas E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042845/
https://ncbi.nlm.nih.gov/pubmed/27526321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3641
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