Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes

Single-cell transcriptomic analysis is widely used to study human tumors. However it remains challenging to distinguish normal cell types in the tumor microenvironment from malignant cells and to resolve clonal substructure within the tumor. To address these challenges, we developed an integrative B...

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Udgivet i:Nat Biotechnol
Main Authors: Gao, Ruli, Bai, Shanshan, Henderson, Ying C., Lin, Yiyun, Schalck, Aislyn, Yan, Yun, Kumar, Tapsi, Hu, Min, Sei, Emi, Davis, Alexander, Wang, Fang, Shaitelman, Simona F., Wang, Jennifer Rui, Chen, Ken, Moulder, Stacy, Lai, Stephen Y., Navin, Nicholas E.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8122019/
https://ncbi.nlm.nih.gov/pubmed/33462507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-00795-2
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