MEDALT: single-cell copy number lineage tracing enabling gene discovery

We present a Minimal Event Distance Aneuploidy Lineage Tree (MEDALT) algorithm that infers the evolution history of a cell population based on single-cell copy number (SCCN) profiles, and a statistical routine named lineage speciation analysis (LSA), whichty facilitates discovery of fitness-associat...

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Publicado en:Genome Biol
Autores principales: Wang, Fang, Wang, Qihan, Mohanty, Vakul, Liang, Shaoheng, Dou, Jinzhuang, Han, Jincheng, Minussi, Darlan Conterno, Gao, Ruli, Ding, Li, Navin, Nicholas, Chen, Ken
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901082/
https://ncbi.nlm.nih.gov/pubmed/33622385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02291-5
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