Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection

We reported that arginase 2 (ARG2) deletion results in increased gastritis and decreased bacterial burden during Helicobacter pylori infection in mice. Our studies implicated a potential role for inducible nitric oxide (NO) synthase (NOS2), as Arg2(−/−) mice exhibited increased NOS2 levels in gastri...

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Bibliographic Details
Published in:Amino Acids
Main Authors: Hardbower, Dana M., Asim, Mohammad, Murray-Stewart, Tracy, Casero, Robert A., Verriere, Thomas, Lewis, Nuruddeen D., Chaturvedi, Rupesh, Piazuelo, M. Blanca, Wilson, Keith T.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042810/
https://ncbi.nlm.nih.gov/pubmed/27074721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-016-2231-2
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