Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production

BACKGROUND & AIMS: Helicobacter pylori-induced immune responses fail to eradicate the bacterium. Nitric oxide (NO) can kill H. pylori. However, translation of inducible NO synthase (iNOS) and NO generation by H. pylori-stimulated macrophages is inhibited by the polyamine spermine derived from or...

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Detalhes bibliográficos
Main Authors: Chaturvedi, Rupesh, Asim, Mohammad, Hoge, Svea, Lewis, Nuruddeen D., Singh, Kshipra, Barry, Daniel P., de Sablet, Thibaut, Piazuelo, M. Blanca, Sarvaria, Aditya R., Cheng, Yulan, Closs, Ellen I., Casero, Robert A., Gobert, Alain P., Wilson, Keith T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967614/
https://ncbi.nlm.nih.gov/pubmed/20600019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.06.060
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