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Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production

BACKGROUND & AIMS: Helicobacter pylori-induced immune responses fail to eradicate the bacterium. Nitric oxide (NO) can kill H. pylori. However, translation of inducible NO synthase (iNOS) and NO generation by H. pylori-stimulated macrophages is inhibited by the polyamine spermine derived from or...

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Bibliografiske detaljer
Main Authors: Chaturvedi, Rupesh, Asim, Mohammad, Hoge, Svea, Lewis, Nuruddeen D., Singh, Kshipra, Barry, Daniel P., de Sablet, Thibaut, Piazuelo, M. Blanca, Sarvaria, Aditya R., Cheng, Yulan, Closs, Ellen I., Casero, Robert A., Gobert, Alain P., Wilson, Keith T.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967614/
https://ncbi.nlm.nih.gov/pubmed/20600019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.06.060
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