Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene

Osteosarcoma (OS) is the most common primary malignant tumor of bone, showing complex chromosomal rearrangements but with few known consistent changes. Deeper biological understanding is crucial to find new therapies to improve patient survival. We have sequenced the whole exome of two primary tumor...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Barøy, Tale, Chilamakuri, Chandra S. R., Lorenz, Susanne, Sun, Jinchang, Bruland, Øyvind S., Myklebost, Ola, Meza-Zepeda, Leonardo A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042545/
https://ncbi.nlm.nih.gov/pubmed/27685995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163859
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