Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene

Osteosarcoma (OS) is the most common primary malignant tumor of bone, showing complex chromosomal rearrangements but with few known consistent changes. Deeper biological understanding is crucial to find new therapies to improve patient survival. We have sequenced the whole exome of two primary tumor...

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Veröffentlicht in:PLoS One
Hauptverfasser: Barøy, Tale, Chilamakuri, Chandra S. R., Lorenz, Susanne, Sun, Jinchang, Bruland, Øyvind S., Myklebost, Ola, Meza-Zepeda, Leonardo A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042545/
https://ncbi.nlm.nih.gov/pubmed/27685995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163859
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