Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations

In contrast to many other sarcoma subtypes, the chaotic karyotypes of osteosarcoma have precluded the identification of pathognomonic translocations. We here report hundreds of genomic rearrangements in osteosarcoma cell lines, showing clear characteristics of microhomology-mediated break-induced re...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lorenz, Susanne, Barøy, Tale, Sun, Jinchang, Nome, Torfinn, Vodák, Daniel, Bryne, Jan-Christian, Håkelien, Anne-Mari, Fernandez-Cuesta, Lynnette, Möhlendick, Birte, Rieder, Harald, Szuhai, Karoly, Zaikova, Olga, Ahlquist, Terje C., Thomassen, Gard O. S., Skotheim, Rolf I., Lothe, Ragnhild A., Tarpey, Patrick S., Campbell, Peter, Flanagan, Adrienne, Myklebost, Ola, Meza-Zepeda, Leonardo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868685/
https://ncbi.nlm.nih.gov/pubmed/26672768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6567
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