Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations

In contrast to many other sarcoma subtypes, the chaotic karyotypes of osteosarcoma have precluded the identification of pathognomonic translocations. We here report hundreds of genomic rearrangements in osteosarcoma cell lines, showing clear characteristics of microhomology-mediated break-induced re...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Lorenz, Susanne, Barøy, Tale, Sun, Jinchang, Nome, Torfinn, Vodák, Daniel, Bryne, Jan-Christian, Håkelien, Anne-Mari, Fernandez-Cuesta, Lynnette, Möhlendick, Birte, Rieder, Harald, Szuhai, Karoly, Zaikova, Olga, Ahlquist, Terje C., Thomassen, Gard O. S., Skotheim, Rolf I., Lothe, Ragnhild A., Tarpey, Patrick S., Campbell, Peter, Flanagan, Adrienne, Myklebost, Ola, Meza-Zepeda, Leonardo A.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868685/
https://ncbi.nlm.nih.gov/pubmed/26672768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6567
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