APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation

Apurinic/apyrimidinic endonuclease 1 (APE1) is the main mammalian AP-endonuclease responsible for the repair of endogenous DNA damage through the base excision repair (BER) pathway. Molecular epidemiological studies have identified several genetic variants associated with human diseases, but a well-...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lirussi, Lisa, Antoniali, Giulia, D'Ambrosio, Chiara, Scaloni, Andrea, Nilsen, Hilde, Tell, Gianluca
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041981/
https://ncbi.nlm.nih.gov/pubmed/27050370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8477
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