ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells

ZFP57 is necessary for maintaining repressive epigenetic modifications at Imprinting control regions (ICRs). In mouse embryonic stem cells (ESCs), ZFP57 binds ICRs (ICR(BS)) and many other loci (non-ICR(BS)). To address the role of ZFP57 on all its target sites, we performed high-throughput and mult...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Riso, Vincenzo, Cammisa, Marco, Kukreja, Harpreet, Anvar, Zahra, Verde, Gaetano, Sparago, Angela, Acurzio, Basilia, Lad, Shraddha, Lonardo, Enza, Sankar, Aditya, Helin, Kristian, Feil, Robert, Fico, Annalisa, Angelini, Claudia, Grimaldi, Giovanna, Riccio, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041456/
https://ncbi.nlm.nih.gov/pubmed/27257070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw505
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