Alternative Splice Variants Modulates Dominant-Negative Function of Helios in T-Cell Leukemia

The molecular defects which lead to multistep incidences of human T-cell leukemia have yet to be identified. The DNA-binding protein Helios (known as IKZF2), a member of the Ikaros family of Krüppel-like zinc-finger proteins, functions pivotally in T-cell differentiation and activation. In this stud...

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Vydáno v:PLoS One
Hlavní autoři: Zhao, Shaorong, Liu, Wei, Li, Yinghui, Liu, Pengjiang, Li, Shufang, Dou, Daolei, Wang, Yue, Yang, Rongcun, Xiang, Rong, Liu, Feifei
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040427/
https://ncbi.nlm.nih.gov/pubmed/27681508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163328
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