The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity

The telomerase catalytic subunit (hTERT) is an essential component of the holoenzyme complex that adds telomeric repeats to the ends of human chromosomes. Maintenance of telomeres by telomerase or another mechanism is required for cell immortalization, and loss of telomeric DNA has been proposed as...

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Hlavní autoři: Colgin, Lorel M, Wilkinson, Christen, Englezou, Anna, Kilian, Andrzej, Robinson, Murray O, Redder, Roger R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature America, Inc. 2000
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1507985/
https://ncbi.nlm.nih.gov/pubmed/11191109
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