The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity

The telomerase catalytic subunit (hTERT) is an essential component of the holoenzyme complex that adds telomeric repeats to the ends of human chromosomes. Maintenance of telomeres by telomerase or another mechanism is required for cell immortalization, and loss of telomeric DNA has been proposed as...

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Autores principales: Colgin, Lorel M, Wilkinson, Christen, Englezou, Anna, Kilian, Andrzej, Robinson, Murray O, Redder, Roger R
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature America, Inc. 2000
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1507985/
https://ncbi.nlm.nih.gov/pubmed/11191109
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