TGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5

Recent studies have found that vasogenic brain edema is present during hepatic encephalopathy following acute liver failure and is dependent upon increased matrix metalloproteinase 9 (MMP9) activity and downregulation of tight junction proteins. Furthermore, circulating transforming growth factor β1...

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Veröffentlicht in:Lab Invest
Hauptverfasser: McMillin, Matthew, Frampton, Gabriel, Seiwell, Andrew, Patel, Nisha, Jacobs, Amber, DeMorrow, Sharon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040071/
https://ncbi.nlm.nih.gov/pubmed/26006017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2015.70
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