TGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5

Eitemau Tebyg

• Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice
  gan: McMillin, Matthew, et al.
  Cyhoeddwyd: (2019)
• Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline
  gan: McMillin, Matthew, et al.
  Cyhoeddwyd: (2014)
• Thrombospondin-1 Exacerbates Acute Liver Failure and Hepatic Encephalopathy Pathology in Mice by Activating Transforming Growth Factor β1
  gan: Jefferson, Brandi, et al.
  Cyhoeddwyd: (2020)
• The Direct Contribution of Astrocytes and Microglia to the Pathogenesis of Hepatic Encephalopathy
  gan: Jaeger, Victoria, et al.
  Cyhoeddwyd: (2019)
• Fractalkine suppression during hepatic encephalopathy promotes neuroinflammation in mice
  gan: McMillin, Matthew, et al.
  Cyhoeddwyd: (2016)