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STRUM: structure-based prediction of protein stability changes upon single-point mutation

Motivation: Mutations in human genome are mainly through single nucleotide polymorphism, some of which can affect stability and function of proteins, causing human diseases. Several methods have been proposed to predict the effect of mutations on protein stability; but most require features from exp...

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Publicado en:Bioinformatics
Autores principales: Quan, Lijun, Lv, Qiang, Zhang, Yang
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039926/
https://ncbi.nlm.nih.gov/pubmed/27318206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw361
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