Embryonic type Na(+) channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome

SCN5A is abundant in heart and has a major role in I(Na). Loss-of-function mutation in SCN5A results in Brugada syndrome (BrS), which causes sudden death in adults. It remains unclear why disease phenotype does not manifest in the young even though mutated SCN5A is expressed in the young. The aim of...

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מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Okata, Shinichiro, Yuasa, Shinsuke, Suzuki, Tomoyuki, Ito, Shogo, Makita, Naomasa, Yoshida, Tetsu, Li, Min, Kurokawa, Junko, Seki, Tomohisa, Egashira, Toru, Aizawa, Yoshiyasu, Kodaira, Masaki, Motoda, Chikaaki, Yozu, Gakuto, Shimojima, Masaya, Hayashiji, Nozomi, Hashimoto, Hisayuki, Kuroda, Yusuke, Tanaka, Atsushi, Murata, Mitsushige, Aiba, Takeshi, Shimizu, Wataru, Horie, Minoru, Kamiya, Kaichiro, Furukawa, Tetsushi, Fukuda, Keiichi
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2016
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039759/
https://ncbi.nlm.nih.gov/pubmed/27677334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34198
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