Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes

Andersen-Tawil syndrome (ATS) is a rare inherited channelopathy. The cardiac phenotype in ATS is typified by a prominent U wave and ventricular arrhythmia. An effective treatment for this disease remains to be established. We reprogrammed somatic cells from three ATS patients to generate induced plu...

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Udgivet i:Biochem Biophys Rep
Main Authors: Kuroda, Yusuke, Yuasa, Shinsuke, Watanabe, Yasuhide, Ito, Shogo, Egashira, Toru, Seki, Tomohisa, Hattori, Tetsuhisa, Ohno, Seiko, Kodaira, Masaki, Suzuki, Tomoyuki, Hashimoto, Hisayuki, Okata, Shinichiro, Tanaka, Atsushi, Aizawa, Yoshiyasu, Murata, Mitsushige, Aiba, Takeshi, Makita, Naomasa, Furukawa, Tetsushi, Shimizu, Wataru, Kodama, Itsuo, Ogawa, Satoshi, Kokubun, Norito, Horigome, Hitoshi, Horie, Minoru, Kamiya, Kaichiro, Fukuda, Keiichi
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614591/
https://ncbi.nlm.nih.gov/pubmed/28956012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2017.01.002
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