Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels

Mitochondrial diseases are heterogeneous disorders, caused by mitochondrial dysfunction. Mitochondria are not regulated solely by nuclear genomic DNA but by mitochondrial DNA. It is difficult to develop effective therapies for mitochondrial disease because of the lack of mitochondrial disease models...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Kodaira, Masaki, Hatakeyama, Hideyuki, Yuasa, Shinsuke, Seki, Tomohisa, Egashira, Toru, Tohyama, Shugo, Kuroda, Yusuke, Tanaka, Atsushi, Okata, Shinichiro, Hashimoto, Hisayuki, Kusumoto, Dai, Kunitomi, Akira, Takei, Makoto, Kashimura, Shin, Suzuki, Tomoyuki, Yozu, Gakuto, Shimojima, Masaya, Motoda, Chikaaki, Hayashiji, Nozomi, Saito, Yuki, Goto, Yu-ichi, Fukuda, Keiichi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383791/
https://ncbi.nlm.nih.gov/pubmed/25853038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.03.008
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