Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels

Mitochondrial diseases are heterogeneous disorders, caused by mitochondrial dysfunction. Mitochondria are not regulated solely by nuclear genomic DNA but by mitochondrial DNA. It is difficult to develop effective therapies for mitochondrial disease because of the lack of mitochondrial disease models...

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Pubblicato in:FEBS Open Bio
Autori principali: Kodaira, Masaki, Hatakeyama, Hideyuki, Yuasa, Shinsuke, Seki, Tomohisa, Egashira, Toru, Tohyama, Shugo, Kuroda, Yusuke, Tanaka, Atsushi, Okata, Shinichiro, Hashimoto, Hisayuki, Kusumoto, Dai, Kunitomi, Akira, Takei, Makoto, Kashimura, Shin, Suzuki, Tomoyuki, Yozu, Gakuto, Shimojima, Masaya, Motoda, Chikaaki, Hayashiji, Nozomi, Saito, Yuki, Goto, Yu-ichi, Fukuda, Keiichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383791/
https://ncbi.nlm.nih.gov/pubmed/25853038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.03.008
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