4-isothiocyanate-2, 2, 6, 6-tetramethyl piperidinooxyl inhibits angiogenesis by suppressing VEGFR2 and Tie2 phosphorylation

Reactive oxygen species (ROS) are involved in the signaling pathway and are triggered by angiogenic factors, including vascular endothelial growth factor and angiopoietins. 4-isothiocyanate-2, 2, 6, 6-tetramethyl piperidinooxyl (4-ISO-Tempo) is one of the nitroxides that exhibits antioxidant activit...

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Bibliographic Details
Published in:Oncol Lett
Main Authors: Liu, Yuanyuan, Gao, Jing, Huang, Shuangsheng, Hu, Lamei, Wang, Zhiqiang, Wang, Zheyuan, Chen, Xiao, Zhang, Xiaoyu, Li, Wenguang
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2016
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038461/
https://ncbi.nlm.nih.gov/pubmed/27698866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2016.4948
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