An Aromatic Diamidine That Targets Kinetoplast DNA, Impairs the Cell Cycle in Trypanosoma cruzi, and Diminishes Trypomastigote Release from Infected Mammalian Host Cells

Trypanosoma cruzi is the etiological agent of Chagas disease, affecting approximately 10 million people in the Americas and with some 40 million people at risk. The objective of this study was to evaluate the anti-T. cruzi activity of three new diamidines that have a 3,4-ethylenedioxy extension of t...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Girard, Richard M. B. M., Crispim, Marcell, Stolić, Ivana, Damasceno, Flávia Silva, Santos da Silva, Marcelo, Pral, Eizabeth Mieko Furusho, Elias, Maria Carolina, Bajić, Miroslav, Silber, Ariel Mariano
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038236/
https://ncbi.nlm.nih.gov/pubmed/27431229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01595-15
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