A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites both In Vitro and In Vivo by Targeting Type IB Topoisomerase

Visceral leishmaniasis is a fatal parasitic disease, and there is an emergent need for development of effective drugs against this neglected tropical disease. We report here the development of a novel spirooxindole derivative, N-benzyl-2,2′α-3,3′,5′,6′,7′,7α,α′-octahydro-2methoxycarbonyl-spiro[indol...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Saha, Sourav, Acharya, Chiranjit, Pal, Uttam, Chowdhury, Somenath Roy, Sarkar, Kahini, Maiti, Nakul C., Jaisankar, Parasuraman, Majumder, Hemanta K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038232/
https://ncbi.nlm.nih.gov/pubmed/27503653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00352-16
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