Recombinant Mucin-Type Fusion Proteins with a Galα1,3Gal Substitution as Clostridium difficile Toxin A Inhibitors

The capability of a recombinant mucin-like fusion protein, P-selectin glycoprotein ligand-1/mouse IgG2b (PSGL-1/mIgG2b), carrying Galα1,3Galβ1,4GlcNAc determinants to bind and inhibit Clostridium difficile toxin A (TcdA) was investigated. The fusion protein, produced by a glyco-engineered stable CHO...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Cherian, Reeja Maria, Jin, Chunsheng, Liu, Jining, Karlsson, Niclas G., Holgersson, Jan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038087/
https://ncbi.nlm.nih.gov/pubmed/27456831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00341-16
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