Collecting duct–specific knockout of endothelin-1 causes hypertension and sodium retention

In vitro studies suggest that collecting duct–derived (CD-derived) endothelin-1 (ET-1) can regulate renal Na reabsorption; however, the physiologic role of CD-derived ET-1 is unknown. Consequently, the physiologic effect of selective disruption of the ET-1 gene in the CD of mice was determined. Mice...

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Detalhes bibliográficos
Main Authors: Ahn, Dowhan, Ge, Yuqiang, Stricklett, Peter K., Gill, Pritmohinder, Taylor, Deborah, Hughes, Alisa K., Yanagisawa, Masashi, Miller, Lance, Nelson, Raoul D., Kohan, Donald E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC503768/
https://ncbi.nlm.nih.gov/pubmed/15314687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421064
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