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Discovery and characterization of sialic acid O-acetylation in group B Streptococcus

Group B Streptococcus (GBS) is the leading cause of human neonatal sepsis and meningitis. The GBS capsular polysaccharide is a major virulence factor and the active principle of vaccines in phase II trials. All GBS capsules have a terminal α2–3-linked sialic acid [N-acetylneuraminic acid (Neu5Ac)],...

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Detalhes bibliográficos
Main Authors: Lewis, Amanda L., Nizet, Victor, Varki, Ajit
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC503750/
https://ncbi.nlm.nih.gov/pubmed/15263085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403010101
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