NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharides in Group B Streptococcus

Group B Streptococcus (GBS) is a common cause of neonatal sepsis and meningitis. A major GBS virulence determinant is its sialic acid (Sia)-capped capsular polysaccharide (CPS). Recently, we discovered the presence and genetic basis of capsular Sia O-acetylation in GBS. We now characterize a GBS Sia...

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Bibliografiske detaljer
Main Authors: Lewis, Amanda L., Cao, Hongzhi, Patel, Silpa K., Diaz, Sandra, Ryan, Wesley, Carlin, Aaron F., Thon, Vireak, Lewis, Warren G., Varki, Ajit, Chen, Xi, Nizet, Victor
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2588433/
https://ncbi.nlm.nih.gov/pubmed/17646166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700340200
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