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Soluble adenylyl cyclase is essential for proper lysosomal acidification

Lysosomes, the degradative organelles of the endocytic and autophagic pathways, function at an acidic pH. Lysosomes are acidified by the proton-pumping vacuolar ATPase (V-ATPase), but the molecular processes that set the organelle’s pH are not completely understood. In particular, pH-sensitive signa...

詳細記述

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書誌詳細
出版年:J Gen Physiol
主要な著者: Rahman, Nawreen, Ramos-Espiritu, Lavoisier, Milner, Teresa A., Buck, Jochen, Levin, Lonny R.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037342/
https://ncbi.nlm.nih.gov/pubmed/27670898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611606
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