A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

The inter- and intra-tumor heterogeneity of breast cancer needs to be adequately captured in pre-clinical models. We have created a large collection of breast cancer patient-derived tumor xenografts (PDTXs), in which the morphological and molecular characteristics of the originating tumor are preser...

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Published in:Cell
Main Authors: Bruna, Alejandra, Rueda, Oscar M., Greenwood, Wendy, Batra, Ankita Sati, Callari, Maurizio, Batra, Rajbir Nath, Pogrebniak, Katherine, Sandoval, Jose, Cassidy, John W., Tufegdzic-Vidakovic, Ana, Sammut, Stephen-John, Jones, Linda, Provenzano, Elena, Baird, Richard, Eirew, Peter, Hadfield, James, Eldridge, Matthew, McLaren-Douglas, Anne, Barthorpe, Andrew, Lightfoot, Howard, O’Connor, Mark J., Gray, Joe, Cortes, Javier, Baselga, Jose, Marangoni, Elisabetta, Welm, Alana L., Aparicio, Samuel, Serra, Violeta, Garnett, Mathew J., Caldas, Carlos
Format: Artigo
Language:Inglês
Published: Cell Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037319/
https://ncbi.nlm.nih.gov/pubmed/27641504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.041
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