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Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711

Iron-regulatory protein 1 (IRP1) is a dual-function protein with mutually exclusive roles as a posttranscriptional regulator of animal-cell iron metabolism or as the cytosolic isoform of the iron–sulfur enzyme aconitase (c-acon). Much effort has focused on the role of IRP1 in posttranscriptional gen...

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Detalhes bibliográficos
Main Authors: Pitula, Joseph S., Deck, Kathryn M., Clarke, Stephen L., Anderson, Sheila A., Vasanthakumar, Aparna, Eisenstein, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC503718/
https://ncbi.nlm.nih.gov/pubmed/15263083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404308101
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