Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children

Predictive performance of physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) models of drugs predominantly eliminated through kidney in the pediatric population was evaluated. After optimization using adult clinical data, the verified PBPK models can predict 33 of 34...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Zhou, W, Johnson, TN, Xu, H, Cheung, SYA, Bui, KH, Li, J, Al‐Huniti, N, Zhou, D
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036422/
https://ncbi.nlm.nih.gov/pubmed/27566992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12101
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