Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children

Predictive performance of physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) models of drugs predominantly eliminated through kidney in the pediatric population was evaluated. After optimization using adult clinical data, the verified PBPK models can predict 33 of 34...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:CPT Pharmacometrics Syst Pharmacol
Hlavní autoři: Zhou, W, Johnson, TN, Xu, H, Cheung, SYA, Bui, KH, Li, J, Al‐Huniti, N, Zhou, D
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036422/
https://ncbi.nlm.nih.gov/pubmed/27566992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12101
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky