Physiologically Based Pharmacokinetic Modeling for Olaparib Dosing Recommendations: Bridging Formulations, Drug Interactions, and Patient Populations

We report physiologically based pharmacokinetic‐modeling analyses to determine olaparib (tablet or capsule) drug–drug interactions (DDIs). Verified DDI simulations provided dose recommendations for olaparib coadministration with clinically relevant CYP3A4 modulators to eliminate potential risk to pa...

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Veröffentlicht in:Clin Pharmacol Ther
Hauptverfasser: Pilla Reddy, Venkatesh, Bui, Khanh, Scarfe, Graeme, Zhou, Diansong, Learoyd, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585620/
https://ncbi.nlm.nih.gov/pubmed/29717476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1103
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