Physiologically Based Pharmacokinetic Modeling for Olaparib Dosing Recommendations: Bridging Formulations, Drug Interactions, and Patient Populations

We report physiologically based pharmacokinetic‐modeling analyses to determine olaparib (tablet or capsule) drug–drug interactions (DDIs). Verified DDI simulations provided dose recommendations for olaparib coadministration with clinically relevant CYP3A4 modulators to eliminate potential risk to pa...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Pilla Reddy, Venkatesh, Bui, Khanh, Scarfe, Graeme, Zhou, Diansong, Learoyd, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585620/
https://ncbi.nlm.nih.gov/pubmed/29717476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1103
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