Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes

Doxorubicin is a widely used and effective chemotherapy drug. However, cardiac and skeletal muscle toxicity of doxorubicin limits its use. Inhibiting myostatin/activin signalling can prevent muscle atrophy, but its effects in chemotherapy-induced muscle wasting are unknown. In the present study we i...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Nissinen, T. A., Degerman, J., Räsänen, M., Poikonen, A. R., Koskinen, S., Mervaala, E., Pasternack, A., Ritvos, O., Kivelä, R., Hulmi, J. J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036092/
https://ncbi.nlm.nih.gov/pubmed/27666826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32695
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