Histone Deacetylase Inhibitor Phenylbutyrate Exaggerates Heart Failure in Pressure Overloaded Mice independently of HDAC inhibition

4-Sodium phenylbutyrate (PBA) has been reported to inhibit endoplasmic reticulum stress and histone deacetylation (HDAC), both of which are novel therapeutic targets for cardiac hypertrophy and heart failure. However, it is unclear whether PBA can improve heart function. Here, we tested the effects...

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Vydáno v:Sci Rep
Hlavní autoři: Ma, Jing, Luo, Tao, Zeng, Zhi, Fu, Haiying, Asano, Yoshihiro, Liao, Yulin, Minamino, Tetsuo, Kitakaze, Masafumi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036044/
https://ncbi.nlm.nih.gov/pubmed/27667442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34036
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