Inhibition of histone deacetylase (HDAC) by 4-phenylbutyrate results in increased junctional conductance between rat corpora smooth muscle cells

4-phenylbutyrate (4-PB) has been shown to increase the protein content in a number of cells types. One such protein is Connexin43 (Cx43). We show here that 4-phenylbutyrate exposure results in significantly elevated cell to cell coupling, as determined by dual whole cell patch clamp. Incubation with...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Wang, Hong Zhan, Rosati, Barbara, Gordon, Chris, Valiunas, Virginijus, McKinnon, David, Cohen, Ira S., Brink, Peter R.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2015
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315027/
https://ncbi.nlm.nih.gov/pubmed/25691868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00009
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