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WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity

The anaphase-promoting complex/cyclosome (APC/C) is a large multimeric cullin–RING E3 ubiquitin ligase that orchestrates cell-cycle progression by targeting cell-cycle regulatory proteins for destruction via the ubiquitin proteasome system. The APC/C assembly comprises two scaffolding subcomplexes:...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Li, Qiuhong, Chang, Leifu, Aibara, Shintaro, Yang, Jing, Zhang, Ziguo, Barford, David
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035875/
https://ncbi.nlm.nih.gov/pubmed/27601667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607147113
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