A High Capacity Polymeric Micelle of Paclitaxel: Implication of High Dose Drug Therapy to Safety and In Vivo Anti-Cancer Activity

The poor solubility of paclitaxel (PTX), the commercially most successful anticancer drug, has long been hampering the development of suitable formulations. Here, we present translational evaluation of a nanoformulation of PTX, which is characterized by a facile preparation, extraordinary high drug...

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Veröffentlicht in:Biomaterials
Hauptverfasser: He, Zhijian, Wan, Xiaomeng, Schulz, Anita, Bludau, Herdis, Dobrovolskaia, Marina A., Stern, Stephan T., Montgomery, Stephanie A., Yuan, Hong, Li, Zibo, Alakhova, Daria, Sokolsky, Marina, Darr, David B., Perou, Charles M., Jordan, Rainer, Luxenhofer, Robert, Kabanov, Alexander V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035646/
https://ncbi.nlm.nih.gov/pubmed/27315213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2016.06.002
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