Poly(2-oxazoline) based Micelles with High Capacity for 3rd Generation Taxoids: preparation, in vitro and in vivo evaluation

The clinically and commercially successful taxanes, paclitaxel and docetaxel suffer from two major drawbacks, namely their very low aqueous solubility and the risk of developing resistance. Here, we present a method that overcomes both drawbacks in a very simple manner. We formulated 3(rd) generatio...

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Publicat a:J Control Release
Autors principals: He, Zhijian, Schulz, Anita, Wan, Xiaomeng, Seitz, Joshua, Bludau, Herdis, Alakhova, Daria Y., Darr, David B., Perou, Charles M., Jordan, Rainer, Ojima, Iwao, Kabanov, Alexander V., Luxenhofer, Robert
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479148/
https://ncbi.nlm.nih.gov/pubmed/25725361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.02.024
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