Co-delivery of Paclitaxel and Cisplatin in Poly(2-oxazoline) Polymeric Micelles: Implications for Drug Loading, Release, Pharmacokinetics and Outcome of Ovarian and Breast Cancer Treatments

Concurrent delivery of multiple drugs using nanoformulations can improve outcomes of cancer treatments. Here we demonstrate that this approach can be used to improve the paclitaxel (PTX) and alkylated cisplatin prodrug combination therapy of ovarian and breast cancer. The drugs are co-loaded in the...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biomaterials
Auteurs principaux: Wan, Xiaomeng, Beaudoin, James J., Vinod, Natasha, Min, Yuanzeng, Makita, Naoki, Bludau, Herdis, Jordan, Rainer, Wang, Andrew, Sokolsky, Marina, Kabanov, Alexander V.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331221/
https://ncbi.nlm.nih.gov/pubmed/30415101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2018.10.032
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