Preferential binding to dopamine D(3) over D(2) receptors by cariprazine in patients with schizophrenia using PET with the D(3)/D(2) receptor ligand [(11)C]-(+)-PHNO

RATIONALE: Second-generation antipsychotics occupy dopamine D(2) receptors and act as antagonists or partial agonists at these receptors. While these drugs alleviate positive symptoms in patients with schizophrenia, they are less effective for treating cognitive deficits and negative symptoms. Dopam...

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Girgis, Ragy R., Slifstein, Mark, D’Souza, Deepak, Lee, Yih, Periclou, Antonia, Ghahramani, Parviz, Laszlovszky, István, Durgam, Suresh, Adham, Nika, Nabulsi, Nabeel, Huang, Yiyun, Carson, Richard E., Kiss, Béla, Kapás, Margit, Abi-Dargham, Anissa, Rakhit, Ashok
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035321/
https://ncbi.nlm.nih.gov/pubmed/27525990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-016-4382-y
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