Preferential binding to dopamine D(3) over D(2) receptors by cariprazine in patients with schizophrenia using PET with the D(3)/D(2) receptor ligand [(11)C]-(+)-PHNO

RATIONALE: Second-generation antipsychotics occupy dopamine D(2) receptors and act as antagonists or partial agonists at these receptors. While these drugs alleviate positive symptoms in patients with schizophrenia, they are less effective for treating cognitive deficits and negative symptoms. Dopam...

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Detalles Bibliográficos
Publicado en:Psychopharmacology (Berl)
Main Authors: Girgis, Ragy R., Slifstein, Mark, D’Souza, Deepak, Lee, Yih, Periclou, Antonia, Ghahramani, Parviz, Laszlovszky, István, Durgam, Suresh, Adham, Nika, Nabulsi, Nabeel, Huang, Yiyun, Carson, Richard E., Kiss, Béla, Kapás, Margit, Abi-Dargham, Anissa, Rakhit, Ashok
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2016
Assuntos:
Original Investigation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035321/
https://ncbi.nlm.nih.gov/pubmed/27525990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-016-4382-y
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