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Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88(L265P) plasmablasts in vivo
The MYD88(L265P) mutation is found in 2% to 10% of chronic lymphocytic leukemia, 29% of activated B-cell type diffuse large B-cell lymphoma and 90% of Waldenström macroglobulinemia, making it conceptually attractive to treat these malignancies with inhibitors of endosomal Toll-like receptors (TLR9,...
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| Pubblicato in: | Blood |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5034740/ https://ncbi.nlm.nih.gov/pubmed/27458005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-708065 |
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