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Synergistic cooperation and crosstalk between MYD88(L265P) and mutations that dysregulate CD79B and surface IgM

CD79B and MYD88 mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk occurs. Here we analyze the consequences of CD79B and MYD88(L265P) mutations individually and combined in normal activated mouse B lymphocytes. C...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Wang, James Q., Jeelall, Yogesh S., Humburg, Peter, Batchelor, Emma L., Kaya, Sarp M., Yoo, Hee Min, Goodnow, Christopher C., Horikawa, Keisuke
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584117/
https://ncbi.nlm.nih.gov/pubmed/28701369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161454
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