Synergistic cooperation and crosstalk between MYD88(L265P) and mutations that dysregulate CD79B and surface IgM

CD79B and MYD88 mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk occurs. Here we analyze the consequences of CD79B and MYD88(L265P) mutations individually and combined in normal activated mouse B lymphocytes. C...

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Publicat a:J Exp Med
Autors principals: Wang, James Q., Jeelall, Yogesh S., Humburg, Peter, Batchelor, Emma L., Kaya, Sarp M., Yoo, Hee Min, Goodnow, Christopher C., Horikawa, Keisuke
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584117/
https://ncbi.nlm.nih.gov/pubmed/28701369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161454
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