Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii

We created and tested multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant (gluco glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) for their ability to protect against Toxoplasma gondii in HLA transgenic mice. Our constructs each included 5 of our best down-selected C...

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Pubblicato in:JCI Insight
Autori principali: El Bissati, Kamal, Chentoufi, Aziz A., Krishack, Paulette A., Zhou, Ying, Woods, Stuart, Dubey, Jitender P., Vang, Lo, Lykins, Joseph, Broderick, Kate E., Mui, Ernest, Suzuki, Yasuhiro, Sa, Qila, Bi, Stephanie, Cardona, Nestor, Verma, Shiv K., Fraczek, Laura, Reardon, Catherine A., Sidney, John, Alexander, Jeff, Sette, Alessandro, Vedvick, Tom, Fox, Chris, Guderian, Jeffrey A., Reed, Steven, Roberts, Craig W., McLeod, Rima
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033759/
https://ncbi.nlm.nih.gov/pubmed/27699241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85955
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