Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii

We created and tested multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant (gluco glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) for their ability to protect against Toxoplasma gondii in HLA transgenic mice. Our constructs each included 5 of our best down-selected C...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: El Bissati, Kamal, Chentoufi, Aziz A., Krishack, Paulette A., Zhou, Ying, Woods, Stuart, Dubey, Jitender P., Vang, Lo, Lykins, Joseph, Broderick, Kate E., Mui, Ernest, Suzuki, Yasuhiro, Sa, Qila, Bi, Stephanie, Cardona, Nestor, Verma, Shiv K., Fraczek, Laura, Reardon, Catherine A., Sidney, John, Alexander, Jeff, Sette, Alessandro, Vedvick, Tom, Fox, Chris, Guderian, Jeffrey A., Reed, Steven, Roberts, Craig W., McLeod, Rima
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033759/
https://ncbi.nlm.nih.gov/pubmed/27699241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85955
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