Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing

Reporter gene assays are a venerable tool for studying signaling pathways, but they lack the throughput and complexity necessary to contribute to a systems-level understanding of endogenous signaling networks. Here we present a parallel reporter assay, Transcription Factor activity sequencing (TF-se...

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Udgivet i:Cell Syst
Main Authors: O'Connell, Daniel J., Kolde, Raivo, Sooknah, Matthew, Graham, Daniel B., Sundberg, Thomas B., Latorre, Isabel, Mikkelsen, Tarjei S., Xavier, Ramnik J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032147/
https://ncbi.nlm.nih.gov/pubmed/27211859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.04.011
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